韦献虎

个人简历
2017/07~至今     广东省科学院微生物研究所,助理研究员 
2017/07~2020/12   广东省科学院,博士后 
2010/09-2017/07   中国科学院大学,有机化学专业,理学博士; 
2006/09-2010/07   沈阳农业大学,生物技术专业,理学学士;
研究领域
主要从事微生物酶底物的开发与应用,食源性致病菌检测方法以及控制研究。
代表性发表论著、论文和专利
1. Fan Li#, Qinghua Ye#, Moutong Chen#, Xinran Xiang, Jumei Zhang, Rui Pang, Liang Xue, Juan Wang, Qihui Gu, Tao Lei, Xianhu Wei, Yu Ding*, Qingping Wu*. Cas12aFDet: A CRISPR/Cas12a-based fluorescence platform for sensitive and specific detection of Listeria monocytogenes serotype 4c, Analytica Chimica Acta, 2021, 1151, 338248. 
2. Xianhu Wei, Ying Feng, Minling Chen, Shuhong Zhang, Moutong Chen, Jumei Zhang, Youxiong Zhang, Qinghua Ye, Yu Ding, Liang Xue, Qingping Wu*. Recent advances in glycosidase probes used in Escherichia coli detection, Current Medicinal Chemistry, 2021, DOI: 10.2174/0929867328999201224111615. 
3. Xianhu Wei, Qingping Wu*, Ying Feng, Minling Chen, Shuhong Zhang, Moutong Chen, Jumei Zhang, Guangzhu Yang, Yu Ding, Xiaojuan Yang, Qinghua Ye, Youxiong Zhang, Qihui Gu, Juan Wang, Shi Wu, Rui Pang, Ying Li. Off-on fluorogenic substrate harnessing ESIPT and AIE features for in situ and long-term tracking of beta-glucuronidase in Escherichia coli, Sensors and Actuators B: Chemical, 2020, 304, 127242. 
4. Xiaojuan Yang, Jiahui Huang, Youxiong Zhang, Shengrong Liu, Ling Chen, Chun Xiao, Haiyan Zeng, Xianhu Wei, Qihui Gu, Ying Li, Juan Wang, Yu Ding, Jumei Zhang, Qingping Wu*. Prevalence, abundance, serovars and antimicrobial resistance of Salmonella isolated from retail raw poultry meat in China, Science of The Total Environment, 2020, 713, 136385. 
5. Yinglong He#, Yu Ding#, Qingping Wu*, Moutong Chen, San’e Zhao, Jumei Zhang, Xianhu Wei, Youxiong Zhang, Jianling Bai, Shuping Mo. Identification of the Potential Biological Preservative Tetramycin A-Producing Strain and Enhancing Its Production, Frontiers in Microbiology, 2020, 10, 2925. 
6. Chengsi Li#, Haiyan Zeng#, Jumei Zhang#, Wenjing He, Na Ling, Moutong Chen, Shi Wu, Tao Lei, Haoming Wu, Yingwang Ye, Yu Ding, Juan Wang, Xianhu Wei, Youxiong Zhang, Qingping Wu*. Prevalence, Antibiotic Susceptibility, and Molecular Characterization of Cronobacter spp. Isolated From Edible Mushrooms in China, Frontiers in Microbiology, 2019, 10, 283. 
7. Moutong Chen#, Jianheng Cheng#, Jumei Zhang, Yuetao Chen, Haiyan Zeng, Liang Xue, Tao Lei, Rui Pang, Shi Wu, Haoming Wu, Shuhong Zhang, Xianhu Wei, Youxiong Zhang, Yu Ding, Qingping Wu*. Isolation, Potential Virulence, and Population Diversity of Listeria monocytogenes From Meat and Meat Products in China, Frontiers in Microbiology, 2019, 10, 946. 
8. Youxiong Zhang, Qingping Wu*, Ming Sun, Jumei Zhang, Shuping Mo, Juan Wang, Xianhu Wei, Jianling Bai. Magnetic-assisted aptamer-based fluorescent assay for allergendetection in food matrix, Sensors and Actuators B: Chemical, 2018, 263: 43-49. 
9. Youxiong Zhang, Qingping Wu*, Xianhu Wei, Jumei Zhang, Shuping Mo. DNA aptamer for use in a fluorescent assay for the shrimp allergen tropomyosin, Microchimica Acta, 2017, 184(2): 633-639. 
10. Xianhu Wei, Qingping Wu*, Jumei Zhang, Youxiong Zhang, Weipeng Guo, Moutong Chen, Qihui Gu, Zhihe Cai, Mianfei Lu. Synthesis of precipitating chromogenic/fluorogenic beta-glucosidase/beta-galactosidase substrates by a new method and their application in the visual detection of foodborne pathogenic bacteria, Chemical Communications, 2017, 53(1): 103-106. 
11. Xianhu Wei, Yanxia Ma, Qingping Wu*, Jumei Zhang, Zhihe Cai, Mianfei Lu. An Improved Helferich Method for the alpha/beta-Stereoselective Synthesis of 4-Methylumbelliferyl Glycosides for the Detection of Microorganisms, Molecules, 2015, 20(12): 21681-21699. 
12.  马延霞, 吴清平*, 张菊梅, 郭伟鹏, 韦献虎. 大肠菌群特异性检测荧光底物MUGal的合成及应用[J]. 现代食品科技, 2014, 30(8): 251-257. 
13.  吴清平*, 韦献虎, 张菊梅, 郭伟鹏. 吲哚酚显色底物的合成及其在微生物检测中的应用研究进展[J]. 化学通报, 2013, 76(7): 580-589. 4.
发明专利: 
1. 韦献虎, 吴清平, 张菊梅, 张淑红, 卢勉飞, 陈谋通, 蔡芷荷, 冯颖, 陈敏玲, 丁郁, 王涓, 张友雄, 古其会. 一种用于检测大肠杆菌O157与非O157大肠杆菌的显色培养基, 国际发明专利, 申请号: PCT/CN2019/115520. 
2. 韦献虎, 吴清平, 张菊梅, 张淑红, 卢勉飞, 陈谋通, 蔡芷荷, 冯颖, 陈敏玲, 丁郁, 王涓, 张友雄, 古其会. 一种用于检测大肠杆菌O157与非O157大肠杆菌的显色培养基, 中国发明专利, 申请号: 201811457345.4. 
3. 韦献虎, 吴清平, 张菊梅, 张淑红, 卢勉飞, 陈谋通, 蔡芷荷, 冯颖, 陈敏玲, 丁郁, 王涓, 张友雄, 古其会. 一种β-葡萄糖醛酸苷酶沉淀型荧光底物合成方法, 中国发明专利, 授权公告日2021.05.25, 专利号: ZL 201811465044.6. 
4. 吴清平, 韦献虎, 张菊梅, 陈谋通, 卢勉飞, 蔡芷荷, 薛亮, 王涓. 一种5-溴-6-氯-3-吲哚辛酯的合成方法, 中国发明专利, 授权公告日2020.03.24, 专利号: ZL 201611095606.3. 
5. 吴清平, 韦献虎, 张菊梅, 郭伟鹏, 陈谋通, 蔡芷荷, 卢勉飞. 一种基于吲哚酚衍生物、2-(苯并噻唑-2′-基)苯酚衍生物的糖苷的合成方法, 中国发明专利, 授权公告日2019.01.08, 专利号: ZL 201610811266.3. 
6. 吴清平, 韦献虎, 马延霞, 张菊梅, 蔡芷荷, 卢勉飞. 一种基于4-甲基伞形酮的合成多种糖苷的方法, 中国发明专利, 授权公告日2018.09.28, 专利号: ZL 201510245244.0.
荣誉奖励
待建
主持项目(省部级以上)
1. 广东省科学技术厅,广东省自然科学基金面上项目,2020A151501324,β-半乳糖苷酶阳性细菌的靶向抑制及其作用机制研究,2019-10至2022-09,10万元,在研。 
2. 广东省科学院,发展专项资金项目,2018GDASCX-1001,酚类抗菌剂的靶向性修饰及其用于选择性培养食源性致病菌,2008-01至2019-12,25万元,已结题。

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