副高级
陈少丹
副研究员 硕士生导师
姓名:陈少丹
性别:女
职称:副研究员
学历:博士研究生
研究方向:天然产物与人类健康
电子邮箱:shaodanchen@126.com
通讯地址:广州市越秀区先烈中路100号大院58号楼
个人简历
研究经历
2019年1月 ~ 至今 广东省微生物研究所副研究员 
2015年6月~2018年12月 广东省微生物研究所助理研究员 
2012年11月~2015年4月 广州中医药大学在站博士后,合作导师:卢传坚教授 
教育经历: 
2009年9月~2012年7月 暨南大学,生物医药工程(天然药物化学方向),博士,导师:姚新生院士 
2006年9月~2009年7月 暨南大学,药物化学,硕士,导师:姚新生院士 
2006年9月~2009年7月 湖南中医药大学,药学,学士
研究领域
中药(及药用真菌)中微量次级代谢产物的定向快速分离和结构鉴定,以及在代谢性疾病(糖尿病,高尿酸血症,恶性肿瘤等)治疗方面的开发和应用;中药活性多糖的分离纯化、结构鉴定及其在免疫调节方面的研发;中药及其复方药效物质基础研究及新药开发。
社会任职
代表性发表论著、论文和专利
1. Chen, S.*; Yong, T.; Zhang, Y.; Hu H.; Xie, Y*. Inhibitory effect of five Ganodermaspecies (Agaricomycetes) against key digestive enzymes related to type 2 diabetes mellitus. International Journal of Medicinal Mushrooms 2019, 21: 703-711. 
2. Chen, S.*; Yong, T.; Xiao, C.; Su, J.; Zhang, Y.; Jiao, C.; Xie, Y*. Pyrrole alkaloids and ergosterols from Grifola frondosa exert anti-alpha-glucosidase and anti-proliferative activities. Journal of functional foods 2018, 43: 196-205. 
3. Chen, S.*; Yong, T.; Zhang, Y.; Su, J.; Jiao, C.; Xie, Y. Anti-tumor and anti-angiogenic ergosterols from Ganoderma lucidum. Frontiers in chemistry 2017, 5, 85. 
4. Chen, S.; Li, X.; Yong, T.; Wang, Z.; Su, J.; Jiao, C.; Xie, Y.; Yang, B. B. Cytotoxic lanostane-type triterpenoids from the fruiting bodies of Ganoderma lucidum and their structure-activity relationships. Oncotarget 2017, 8 (6), 10071-10084. 
5. Chen S.; Wang D.; Lu C.*;Zhao R. Two new γ-pyrone glucosides from Paeonia albiflora. Journal of Asian Natural Products Research 2016, 18: 153-158. 
6. Chen S.; Gao J.; Liu J.;Liu B.; Zhao R.; Lu C.* Five new diarylheptanoids from the rhizomes of Curcuma kwangsiensis and their antiproliferative activity. Fitoterapia 2015,102: 67-73. 
7. Chen S.; Lu C.*; Zhao R. Identification and quantitative characterization of PSORI-CM01, a Chinese medicine formula for psoriasis therapy, by liquid chromatography coupled with an LTQ Orbitrap mass spectrometer. Molecules 2015, 20: 1594-1609. 
8. Chen S., Lu C.*, Zhao R. Qualitative and quantitative analysis of Rhizoma Smilacis glabrae by ultra high performance liquid chromatography coupled with LTQ Orbitrap Mass Spectrometry. Molecules 2014, 19: 10427-10439. 
9. Chen S.; Li T.; Gao H.*;Zhu, Q.;Lu C.; Wu, H.; Peng, T.; Yao, X*. Anti HSV-1 flavonoid derivatives tethered with houttuynin from Houttuynia cordata. Planta Medica 2013, 79, 1742-1748. 
10. Chen, S.; Gao, H.*; Zhu, Q.; Wang, Y.; Li, T.; Mu, Z.; Wu, H.; Peng, T.; Yao, X.* Houttuynoids A-E, anti-Herpes simplex virus active flavonoids with novel skeletons from Houttuynia cordata. Organic Letters 2012, 14: 1772-1775. 
参与发表论文 
1. Chen, X.; Li, S.; Li, D.; Li, M.; Su, Z.; Lai, X.; Zhou, C.; Chen, S.; Li, S.; Yang, X.; Su, J. *; Zhang, Y.* Ethanol extract of Brucea javanica seed inhibit triple-negative breast cancer by restraining autophagy via PI3K/Akt/mTOR pathway. Frontiers in Pharmacology 2020, 11: 606. 
2. Chen, X.; Li, M.; Li, D.; Luo, T.; Xie, Y.; Gao, L.; Zhang, Y.; Chen, S.; Li, S.; Huang, G.; Li, W.; Su, J.*; Lai X.* Ethanol extract of Pycnoporus sanguineus relieves the dextran sulfate sodium-induced experimental colitis by suppressing helper T cell-mediated inflammation via apoptosis induction. Biomedicine & Pharmacotherapy 2020, 127:110212. 
3. Li, D.; Gao, L.; Li, M.; Luo, Y.; Xie, Y.; Luo, T.; Su, L.; Yong, T.; Chen, S.; Jiao, C.; Su, J. *; Huang, S.* Polysaccharide from spore of Ganoderma lucidum ameliorates paclitaxel-induced intestinal barrier injury: Apoptosis inhibition by reversing microtubule polymerization. Biomedicine & Pharmacotherapy 2020, 130:110539. 
4. Yong, T.*; Chen, S.; Xie, Y.; Shuai, O.; Li, X.; Chen, D.; Su, J.; Jiao, C.; Liang, Y. Hypouricemic effects of extracts from Agrocybe aegerita on hyperuricemia mice and virtual prediction of bioactives by molecular docking. Frontiers in Pharmacology 2018, 9: 498 
5. Yong, T.*; Chen, S.; Xie, Y.; Chen, D.; Su, J.; Shuai, O.; Jiao, C.; Zuo, D. Cordycepin, a Characteristic bioactive constituent in Cordyceps militaris, ameliorates hyperuricemia through URAT1 in hyperuricemic mice. Frontiers in Microbiology 2018, 9: 58 
6. Yong, T.*; Chen, S.; Xie, Y.; Chen, D.; Su, J.; Shuai, O.; Hu, H.; Zuo, D.; Liang, D. Hypouricemic effects of Armillaria mellea on hyperuricemic mice regulated through OAT1 and CNT2. The American journal of Chinese medicine 2018, 46: 585-599. 
7. Yong, T.*; Chen, S.; Liang, D.; Zuo, D.; Diao, X.; Deng, C.; Wu, Y.; Hu, H.; Xie, Y.; Chen, D. Actions of Inonotus obliquus against hyperuricemia through XOD and bioactives screened by molecular modeling. International Journal of Molecular Sciences 2018, 19: 3222 
8. Yong, T.*; Xie, Y.; Chen, S.; Chen, D.; Su, J.; Jiao, C.; Hu, H.; Xiao, C. Hypouricemic effect of Grifola frondosa on hyperuricemic mice and virtual screening of bioactives by 3D QSAR pharmacophore modeling. Journal of Functional Foods 2018, 40: 582-588 
9. Liang, D.; Yong, T.*; Chen, S.; Xie, Y.; Chen, D.; Zhou, X.; Li, D.; Li, M.; Su, L.; Zuo, D. Hypouricemic effect of 2,5-dihydroxyacetophenone, a computational screened bioactive compound from Ganoderma applanatum, on hyperuricemic mice. International Journal of Molecular Sciences 2018, 19: 1394 
10. Yong, T.*; Li, D.; Li, M.; Liang, D.; Diao, X.; Deng, C.; Chen, S.; Xie, Y.; Chen, D.; Zuo, D. Anti-hyperuricemic effect of 2-hydroxy-4-methoxy-benzophenone-5-sulfonic acid in hyperuricemic mice through XOD. Molecules 2018, 23: 2671 
11. Yong, T.*; Chen, S.; Xie, Y.; Chen, D.; Su, J.; Shuai, O.; Jiao, C.; Zuo, D. Hypouricemic Effects of Ganoderma applanatum in Hyperuricemia Mice through OAT1 and GLUT9. Frontiers in Pharmacology 2017, 8: 996. 
12. Li, T.; Liu, L.; Wu, H.; Chen, S.; Zhu, Q.; Gao, H.; Yu, X.; Wang, Y.; Su, W.; Yao, X., Peng T.* Anti-herpes simplex virus type 1 activity of Houttuynoid A, a flavonoid from Houttuynia cordata Thunb. Antiviral Research 2017, 144: 273-280 
13. Yong, T.*; Zhang, M.; Chen, D.; Shuai, O.; Chen, S.; Su, J.; Jiao, C.; Feng, D.; Xie, Y. Actions of water extract from Cordyceps militaris in hyperuricemic mice induced by potassium oxonate combined with hypoxanthine. Journal of Ethnopharmacology 2016, 194: 403-411. 
14. Liang, F.; Han, Y.; Gao, H.*; Xin, S.; Chen, S.; Wang, N.; Qin, W.; Zhong, H.; Lin, S.; Yao, X.; Li, S.* Kaempferol identified by zebrafish assay and fine fractionations strategy from Dysosma versipellis inhibits angiogenesis through VEGF and FGF Pathways. Scientific Reports 2015, 5: 14468 
15. Gao, H.; Zhao, F.; Chen, G.; Chen, S.; Yu, Y.; Yao, Z.; Lau, BWC .; Wang, Z.; Li, J.; Yao, X.* Bidesmoside triterpenoid glycosides from Stauntonia chinensis and relationship to anti-inflammation. Phytochemistry 2009, 70: 795-806 
授权专利: 
1. 卢传坚,陈少丹,赵瑞芝,高进涛,一种二苯庚烷化合物及其制备方法和应用,中国发明专利,申请号:201410742111X,已授权 
2. 卢传坚,陈少丹,赵瑞芝,高进涛,一种二苯庚烷化合物及其制备方法和应用,中国发明专利,申请号:2014107420884,已授权 
3. 姚新生,彭涛,高昊,朱钦昌,陈少丹,李婷,肖高铿,吴红玲,鱼腥草素杂合黄酮体及其制备方法和用途,中国发明专利,申请号:2012100622373,已授权
荣誉奖励
2018年     广州市珠江科技新星
2016年度   广东省科学技术奖二等奖1 项
2015年度   广州市科学技术三等奖1项。
主持项目(省部级以上)
1. 2018年度国家自然科学基金青年基金项目,81803393,食药用真菌中羊毛甾烷型三萜抑制α-葡萄糖苷酶的构效关系及其降血糖药效研究,2019.01-2021.12,在研。 
2. 2019年度广东省自然科学基金-面上项目,2020A1515011337,药用真菌中羊毛甾烷型三萜抑制α-葡萄糖苷酶活性的构效关系及其降血糖作用机制研究, 2019.10-2022.09,在研。 
3. 广州市科技计划项目珠江科技新星专题,201806010078,灵芝孢子粉及相关产品质量控制关键技术研究, 2018/4-2021/3,在研。 
4. 广东省科技计划项目,2017A030303055, 基于代谢组学策略的灵芝资源品质评价方法的研究,2017.01-2018.12,已验收。 
5. 广东省科技计划项目,2016A030303041,食药用真菌标准组分库的建设,2016.01-2017.12,已验收。
招生信息
受聘于华南农业大学食品学院硕士生导师。